Dissemination Icon

Blood Vessel Dynamics Research & Publications

The following section briefly reports the scientific work behind the VIPER project for fluid therapy and dehydration assessment. For further details and collaborations, please contact us.

Patent Information

Standard Clinical Method for Fluid Therapy Assessment

The most common non-invasive approach in hospital wards for evaluating hydration status and dehydration risk is through ultrasound monitoring of the inferior vena cava and estimating the Caval Index. The physician selects a section of the vein on the longitudinal ultrasound image. This section must be one of the rays emitted by the ultrasound machine. The minimum and maximum diameter (D) of the vein are measured to calculate the Caval Index for fluid therapy management:

Caval Index Formula for Fluid Therapy Assessment
Stiff vein CI = 0 (Overhydration)
Collapsed vein CI = 1 (Dehydration)

Challenges in Vascular Dynamics Monitoring

This process is cumbersome and imprecise for accurate dehydration assessment. It requires many operator steps and makes significant approximations since it does not account for vein geometry or the fact that the ray does not move solidly with the vessel. Moreover, it has strong inter- and intra-operator variability. Consequently, operators often abandon this method, classifying patients simply as "Full" or "Empty," obtaining only a qualitative measurement from the ultrasound, which is non-reportable and represents a significant loss of information for proper fluid therapy management.

Problems with traditional IVC measurement methods for fluid therapy

Solutions and Patent for Dehydration Assessment

Method and apparatus to characterize non-invasively images containing venous blood vessels for improved fluid therapy management
International Publication Number: WO 2018/134726 A1

Bullet point

PC acquisition through frame grabber of video from any ultrasound system for IVC blood vessel analysis

Bullet point

Real-time processing and rendering of vein edges on ultrasound images for precise fluid therapy decisions

IVC vein framing for dehydration assessment

Framing of the vein on longitudinal and/or transverse sections for optimal blood vessel dynamics analysis

Longitudinal section study of IVC for fluid therapy

Study of the transverse longitudinal section for comprehensive vascular dynamics assessment

Real-time edge rendering of IVC for dehydration assessment

Real-time edge rendering for accurate fluid therapy monitoring

Time series extraction from IVC ultrasound for blood vessel dynamics analysis

Time series extraction (area or diameters for each video frame) from which different components can be separated (respiratory and cardiac) for comprehensive dehydration assessment and fluid therapy optimization.